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KMID : 0351819940350040419
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Kyunpook University Medical Journal
1994 Volume.35 No. 4 p.419 ~ p.426
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Desensitization of Alpha 1 Adrenergic Receptor-mediated Contraction of Isolated Rat Aorta
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Choi Do-Heoi
Han Hyung-Soo
Park Jung-Sook
Kim Choong-Young
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Abstract
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We evaluated alpha 1 adrenergic receptor desensitization and decreased contractility in isolated rat aorta. 4 hour exposure to 10-´M of phenylephrine(phenylephrine exposure) decreased phenylephrine(10-10 to 10-´M)-induced contractility. Phenylephrine exposure had no effect on the relaxation by NO releasing agents, such as acetylcholine(10-´ tp 10-´M) and histamine(10-b to 10-´M), but enhanced nitroprusside(10-10 to 10-"M)-induced relaxation. Phenylephrine-induced desensitization was not altered by the presence of methylene blue and i~I-rnonoi~nethyl-L-arginine. After phenylephrine exposure KCI-induced contractility vas decreased but phorbol ester-induced contractility vas not Chan;ed.
From these results we can assume that prolonged phenylephrine exposure alter calcium-dependent contraction mechanism and involve in alpha 1 adrenergic receptor desensitization-mediated decrease in contractility.
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KEYWORD
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protein kinase C, Alpha-desensitization, Contractility
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